Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs

  title={Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs},
  author={Rosalind M. Ridley and T. K. Murray and J. A. Johnson and Harry F. Baker},
  journal={Brain Research},

Basal nucleus lesions in monkeys: recognition memory impairment or visual agnosia?

Lesions of those parts of the NBM which send cholinergic projections to temporal cortex may produce impairments on repeated-trial visual discrimination tasks and on trial-unique novel object discriminations, which are suggested to be similar to those seen after fornix or selective hippocampal lesions.



Cortical cholinergic impairment and behavioral deficits produced by kainic acid lesions of rat magnocellular basal forebrain.

Compared with controls, rats with MNBF lesions were impaired in 24-hr retention, but not acquisition, of a passive avoidance task with escapable footshock and the data suggested a slower rate of learning in MNBF rats.

Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta).

The extreme emotional changes seen after total amygdalectomy were found only in the monkey with the largest subtotal lesion, which suggests that both the hypoemotionality and the successive reversal deficit arise from the same underlying dysfunction.

Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus

A discrepancy between the clinical and animal literature could indicate a true evolutionary shift in the functions of the hippocampus, or, at the other extreme, it could simply reflect the use of incommensurate measures across species.


Monkeys impaired on delayed response following midlateral frontal lesions, control operatees, and unoperated Ss were tested on 2 discrimination re-versals, suggesting that midl lateral frontal lesions produce a discrimination deficit inversely related to the number of trials per problem.

Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

This work has shown that the memory impairment caused by unilateral lesions of the cholinergic nucleus basalis magnocellularis is reversed by grafts into the deafferented neocortex of embryonic neurons of the Cholinergic ventral forebrain, but not by grafting of noncholinergic hippocampal cells.

Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish