Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist

@article{Glowa1992LearningIF,
  title={Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist},
  author={J. Glowa and L. Panlilio and D. Brenneman and I. Gozes and J. Hill},
  journal={Brain Research},
  year={1992},
  volume={570},
  pages={49-53}
}
  • J. Glowa, L. Panlilio, +2 authors J. Hill
  • Published 1992
  • Medicine
  • Brain Research
  • The external envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV) has been shown to be toxic to neurons in culture. To further investigate the neurological effects of gp120, the involvement of this protein with the acquisition of spatial discrimination was assessed. Both native and recombinant gp120 were administered into the cerebral ventricles of adult rats and performance was evaluated in the Morris swim maze. Gp120 treatment retarded acquisition after daily administration… CONTINUE READING
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