Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.

@article{Barakat2010LearningFJ,
  title={Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.},
  author={Monique T Barakat and Eric W. Humke and Matthew P Scott},
  journal={Trends in molecular medicine},
  year={2010},
  volume={16 8},
  pages={337-48}
}
The Hedgehog (Hh) cascade controls cell proliferation, differentiation and patterning of tissues during embryogenesis but is largely suppressed in the adult. The Hh pathway can become reactivated in cancer. Here, we assimilate data from recent studies to understand how and when the Hh pathway is turned on to aid the neoplastic process. Hh signaling is now known to have a role in established tumors, enabling categorization of tumors based on the role Hh signaling plays in their growth. This… CONTINUE READING

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