Learning disturbances following excitotoxic lesion of cholinergic pedunculo-pontine nucleus in the rat

@article{Dellu1991LearningDF,
  title={Learning disturbances following excitotoxic lesion of cholinergic pedunculo-pontine nucleus in the rat},
  author={F. Dellu and Weiss Mayo and J. Cherkaoui and Michel le Moal and Herv{\'e} Simon},
  journal={Brain Research},
  year={1991},
  volume={544},
  pages={126-132}
}
Compared to brain anterior cholinergic systems such as the septo-hippocampal and nucleus basalis-cortical pathways, posterior cholinergic groups have received little attention with respect to their involvement in learning and memory. In this study, the effect of lesion of the cholinergic pedunculo-pontine cell bodies (PPN) by the excitotoxin quisqualic acid was investigated on spontaneous locomotor activity and learning in rats. Behavioral tasks designed to test both reference memory (cross… CONTINUE READING

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