Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity


Reduced insulin/insulin-like growth factor signaling (IIS) is a major cause of symmetrical intrauterine growth retardation (IUGR), an impairment in cell proliferation during prenatal development that results in global growth defects and mental retardation. In Drosophila, chico encodes the only insulin receptor substrate. Similar to other animal models of… (More)
DOI: 10.1186/s13041-016-0217-3


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