Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.

@article{Billings2007LearningDA,
  title={Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.},
  author={Lauren M. Billings and Kim N Green and James McGaugh and Frank M Laferla},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 4},
  pages={751-61}
}
Transgenic mouse models of Alzheimer's disease (AD), such as the 3xTg-AD mice, are instrumental for elucidating genetic, pharmacologic, environmental, and behavioral factors that affect the cognitive phenotype. Here we present the novel findings that longitudinal water-maze spatial training produces a significant, albeit transient, improvement in subsequent learning performance and reduces amyloid beta (Abeta) and tau neuropathology. The 3xTg-AD mice were trained and tested at 3 month intervals… CONTINUE READING

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