Learning and memory in transgenic mice modeling Alzheimer's disease.

@article{Ashe2001LearningAM,
  title={Learning and memory in transgenic mice modeling Alzheimer's disease.},
  author={K. Ashe},
  journal={Learning & memory},
  year={2001},
  volume={8 6},
  pages={301-8}
}
  • K. Ashe
  • Published 2001 in Learning & memory
Recent advances in behavioral analyses of transgenic mouse models of Alzheimer's disease (AD) are discussed, and their impact on our understanding of the molecular basis of cognitive impairment in AD is considered. Studies of the relationship between memory and A Beta in transgenic mice expressing the amyloid precursor protein (APP) and its variants suggest that aging promotes the formation of soluble A Beta assemblies mediating negative effects on memory. A significant component of memory loss… CONTINUE READING

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