Learning and memory dissociation in rats with lesions to the subthalamic nucleus or to the dorsal striatum

  title={Learning and memory dissociation in rats with lesions to the subthalamic nucleus or to the dorsal striatum},
  author={Nicole el Massioui and Fabrice Ch{\'e}ruel and Alexis Faure and Françoise Cond{\'e}},

The involvement of the primate frontal cortex-basal ganglia system in arbitrary visuomotor association learning

The in-depth study of dlPFC and Cd suggests that the frontal cortex-basal ganglia system functions only when competition between learning contexts exist and that the function of the system is dependent on the existence of competition between learned information.

Deep Brain Stimulation of the Subthalamic Nucleus Improves Reward-Based Decision-Learning in Parkinson's Disease

Computational measures of outcome evaluation and reward prediction from PD patients who performed a probabilistic reward-based decision-learning task determined positive effects of STN stimulation on cognitive functions that may benefit PD patients in daily-life association-learning situations.

Title Deep brain stimulation of the subthalamic nucleus improves reward-based decision-learning in Parkinson ' s disease

DBS of the STN has become the treatment of choice in patients whose symptoms are less well controlled by medications (Limousin, although the specific mechanisms underlying its therapeutic effects are still debated).

Surgical Strategies for Parkinson’s Disease Based on Animal Model Data: GPi and STN Inactivation on Various Aspects of Behavior (Motor, Cognitive and Motivational Processes)

This chapter will focus mainly on two major targets and will omit the ventral intermediate nucleus (VIM) of the thalamus that was the initial target for the treatment of tremor in PD patients and the most recent one – the pedunculopontine nucleus – currently chosen to treat the freezing.

Condition interference in rats performing a choice task with switched variable- and fixed-reward conditions

The electrophysiological study suggests that this interfering value-updating is mediated by the prelimbic cortex and dorsomedial striatum, which represented the action-reward associations irrespective of trial conditions.

Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats

The results confirm the specificity of STN involvement in these processes and support the choice of the STN as a target for the treatment of impulse control disorders in Parkinson’s disease and in obsessive compulsive disorders.



Functional Disconnection of the Medial Prefrontal Cortex and Subthalamic Nucleus in Attentional Performance: Evidence for Corticosubthalamic Interaction

Evidence is provided that performance in tasks that require optimal attentional and executive control relies on a corticosubthalamic interaction within the neural circuitry of the basal ganglia, and that some of the deficits observed after bilateral STN lesions (attention and perseveration) may be attributable to a disrupted corticostriatal projection.

Rule-Based Learning Impairment in Rats with Lesions to the Dorsal Striatum

The results of the present study suggest that the dorsal striatum plays an important role in rule-learning ability in Sprague-Dawley rats, when tested on the acquisition and successive shifts in the position of a goal arm in an eight-arm radial maze.

Dissociation of Hippocampal and Striatal Contributions to Spatial Navigation in the Water Maze

The results suggest that the hippocampus mediates the allocentric spatial component of the water maze place task while the dorsomedial striatum may play an important role in the acquisition of the procedural aspects of both place and cue versions of the task.

Bilateral Lesions of the Subthalamic Nucleus Induce Multiple Deficits in an Attentional Task in Rats

The results suggest that STN lesions have multiple, dissociable effects on attentional performance, including discriminative deficits, impulsivity and perseverative behaviour, which is consistent with a hypothesized role of the STN in recent models of basal ganglia function in areaction selection and inhibition.

Activity of neurons of the subthalamic nucleus in relation to motor performance in the cat

The results suggest that a significant proportion of subthalamic cells are involved in the preparation and the initiation phases of the lever-release movement studied, although other hypotheses (e.g. stimulus-related responses) cannot be definitely ruled out.

Effects of transient inactivation of the subthalamic nucleus by local muscimol and APV infusions on performance on the five-choice serial reaction time task in rats

These results reproduce many of the effects of lesions of the STN and are consistent with an integrative role for this structure in pallidal and thalamo-cortical processing.

Alleviation of overtraining reversal effect by transient inactivation of the dorsal striatum

The data show that inactivating the dorsal striatum before each reversal session prevented the overtraining reversal effect observed in control rats, and shows that even though the striatum might normally be part of a routine automatic system, clearly its contribution is not essential.

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex.

Functional heterogeneity within the rat mPFC is demonstrated and it is suggested that the PL is involved in processes through which recently acquired information is used to organize and modify foraging behavior, whereas the AC may play an important role in response flexibility.

The contribution of NMDA receptors in the dorsolateral striatum to egocentric response learning.

The results suggest that NMDA receptors in the dorsolateral striatum are critical for the initial learning of an egocentric response discrimination.