Learning and memory after adrenalectomy-induced hippocampal dentate granule cell degeneration in the rat.

@article{Armstrong1993LearningAM,
  title={Learning and memory after adrenalectomy-induced hippocampal dentate granule cell degeneration in the rat.},
  author={John N. Armstrong and Dan McIntyre and S Neubort and Robert S. Sloviter},
  journal={Hippocampus},
  year={1993},
  volume={3 3},
  pages={359-71}
}
Adrenalectomy (ADX) of normal adult rats causes selective hippocampal dentate granule cell degeneration that is prevented by corticosterone. The ability to destroy this one hippocampal cell type noninvasively made it possible to address the role of the dentate granule cells in learning and memory. Four months after ADX, 31 of 45 rats failed to show obvious granule cell loss and displayed behavior in the Morris water maze that was similar to 16 sham-operated control rats and 16 ADX rats… CONTINUE READING

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