Learning Induces Long-Term Potentiation in the Hippocampus

@article{Whitlock2006LearningIL,
  title={Learning Induces Long-Term Potentiation in the Hippocampus},
  author={Jonathan R. Whitlock and Arnold J. Heynen and Marshall G. Shuler and Mark F. Bear},
  journal={Science},
  year={2006},
  volume={313},
  pages={1093 - 1097}
}
Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction… Expand
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