Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.

@article{Rust2010LearningAR,
  title={Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics.},
  author={Marco B. Rust and Christine B. Gurniak and Marianne Renner and Hugo Vara and Laura Morando and Andreas G{\"o}rlich and Marco Sasso{\'e}-Pognetto and Mumna Al Banchaabouchi and Maurizio Giustetto and Antoine Triller and Daniel Choquet and Walter Witke},
  journal={The EMBO journal},
  year={2010},
  volume={29 11},
  pages={1889-902}
}
Neuronal plasticity is an important process for learning, memory and complex behaviour. Rapid remodelling of the actin cytoskeleton in the postsynaptic compartment is thought to have an important function for synaptic plasticity. However, the actin-binding proteins involved and the molecular mechanisms that in vivo link actin dynamics to postsynaptic physiology are not well understood. Here, we show that the actin filament depolymerizing protein n-cofilin is controlling dendritic spine… CONTINUE READING
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