Leaky gut – concept or clinical entity?

@article{Quigley2016LeakyG,
  title={Leaky gut – concept or clinical entity?},
  author={Eamonn M. M. Quigley},
  journal={Current Opinion in Gastroenterology},
  year={2016},
  volume={32},
  pages={74–79}
}
  • E. Quigley
  • Published 1 March 2016
  • Biology, Medicine
  • Current Opinion in Gastroenterology
Purpose of review This article evaluates the current status of the gut barrier in gastrointestinal disorders. Recent findings The gut barrier is a complex, multicomponent, interactive, and bidirectional entity that includes, but is not restricted to the epithelial cell layer. Intestinal permeability, the phenomenon most readily and commonly studied, reflects just one (albeit an important one) function of the barrier that is intimately related to and interacts with luminal contents, including… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Intestinal permeability defects: is it time to treat?
  • Matthew A. Odenwald, J. Turner
  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2013
TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders. Expand
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
TLDR
The crosstalk between the gut microbiota, the enteroendocrine system, the immune system and the role of intestinal permeability in patients with IBS is highlighted. Expand
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome.
TLDR
The role of the healthy intestinal epithelium as a barrier between the lumen and the rest of the body with a focus on tight junctions is summarized to explore how this increased permeability may elicit immune responses that affect afferent nerves, resulting in the pain associated with IBS. Expand
Intestinal permeability – a new target for disease prevention and therapy
TLDR
Intestinal permeability, which is a feature of intestinal barrier function, is increasingly recognized as being of relevance for health and disease, and therefore, this topic warrants more attention. Expand
Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions.
TLDR
A plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS can be generated. Expand
Intestinal barrier function in health and gastrointestinal disease
TLDR
This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS, and summarizes the components of the intestinal barrier including the tight junction complex within the epithelium. Expand
Importance of disrupted intestinal barrier in inflammatory bowel diseases
&NA; The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and ulcerative colitis (UC), involves the interaction between environmental factors in the intestinal lumenExpand
Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics
TLDR
Several recently proposed therapeutic approaches to treat human IBD are targeted at enhancing different elements of gut barrier function, further supporting a primary role of the epithelium in the pathogenesis of chronic intestinal inflammation and emphasizing the importance of maintaining a healthy and effective intestinal barrier. Expand
Tight junctions and IBS ‐ the link between epithelial permeability, low‐grade inflammation, and symptom generation?
  • T. Piche
  • Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2014
TLDR
Low expression of E‐cadherin, a tight junction protein involved in the regulation of paracellular permeability, in the colonic mucosa of patients with the irritable bowel syndrome with predominance of diarrhea or alternating symptoms, constitutes an improvement in knowledge of epithelial barrier disruption associated with IBS. Expand
Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application.
  • J. Turner
  • Biology, Medicine
  • The American journal of pathology
  • 2006
TLDR
It is now clear that cytoskeletal regulation of barrier function is both an important pathogenic process and that targeted inhibition of myosin light chain kinase, which affects this cytoskeleton-dependent tight junction dysfunction, is an attractive candidate for therapeutic intervention. Expand
...
1
2
3
4
5
...