Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.

@article{Rooney2002LeakySP,
  title={Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.},
  author={Sean M. Rooney and J M Sekiguchi and Chengming Zhu and Hwei Ling Cheng and John Manis and S. Scott Whitlow and Jeff DeVido and Dan Foy and Jayanta Chaudhuri and David N. Lombard and Frederick W Alt},
  journal={Molecular cell},
  year={2002},
  volume={10 6},
  pages={
          1379-90
        }
}
Radiosensitive severe combined immune deficiency in humans results from mutations in Artemis, a protein which, when coupled with DNA-dependent protein kinase catalytic subunit (DNA-PKcs), possesses DNA hairpin-opening activity in vitro. Here, we report that Artemis-deficient mice have an overall phenotype similar to that of DNA-PKcs-deficient mice-including severe combined immunodeficiency associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing… CONTINUE READING

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