Leaky Gut As a Danger Signal for Autoimmune Diseases

  title={Leaky Gut As a Danger Signal for Autoimmune Diseases},
  author={Qinghui Mu and Jay L. Kirby and Christopher M. Reilly and Xin M Luo},
  booktitle={Front. Immunol.},
The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream creating a "leaky gut." In individuals with a genetic predisposition, a leaky gut may allow environmental factors to enter the body and trigger the initiation and development of… CONTINUE READING
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