Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis.

@article{Gitter2000LeaksIT,
  title={Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis.},
  author={Alfred H. Gitter and Kerstin Bendfeldt and J{\"o}rg-Dieter Schulzke and Michael Fromm},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 12},
  pages={1749-53}
}
Current opinion assumes epithelial integrity during spontaneous apoptotic cell death. We measured, for the first time, the local conductances associated with apoptoses and show leaks of up to 280 nS (mean 48 +/- 19 nS) in human intestinal epithelium. The results disprove the dogma that isolated cell apoptosis occurs without affecting the epithelial cell permeability barrier. After induction by tumor necrosis factor alpha (TNF-alpha) the apoptotic leaks were dramatically enhanced: not only was… CONTINUE READING

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