Leading the way: canine models of genomics and disease.

  title={Leading the way: canine models of genomics and disease.},
  author={Abigail L. Shearin and Elaine A Ostrander},
  journal={Disease models & mechanisms},
  volume={3 1-2},
In recent years Canis familiaris, the domestic dog, has drawn considerable attention as a system in which to investigate the genetics of disease susceptibility, morphology and behavior. Because dogs show remarkable intrabreed homogeneity, coupled with striking interbreed heterogeneity, the dog offers unique opportunities to understand the genetic underpinnings of natural variation in mammals, a portion of which is disease susceptibility. In this review, we highlight the unique features of the… CONTINUE READING

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