Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.

@article{Oh2016LeaderContainingUV,
  title={Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.},
  author={Seong-Wook Oh and Koji Onomoto and Mai Wakimoto and Kazuhide Onoguchi and Fumiyoshi Ishidate and Takahiro K Fujiwara and Mitsutoshi Yoneyama and Hiroki Kato and Takashi Fujita},
  journal={PLoS pathogens},
  year={2016},
  volume={12 2},
  pages={
          e1005444
        }
}
RIG-I triggers antiviral responses by recognizing viral RNA (vRNA) in the cytoplasm. However, the spatio-temporal dynamics of vRNA sensing and signal transduction remain elusive. We investigated the time course of events in cells infected with Newcastle disease virus (NDV), a non-segmented negative-strand RNA virus. RIG-I was recruited to viral replication complexes (vRC) and triggered minimal primary type I interferon (IFN) production. RIG-I subsequently localized to antiviral stress granules… CONTINUE READING

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