Lead selection and characterization of antitubercular compounds using the Nested Chemical Library.

@article{Sipos2015LeadSA,
  title={Lead selection and characterization of antitubercular compounds using the Nested Chemical Library.},
  author={Anna Sipos and J{\'a}nos Pat{\'o} and Rita Sz{\'e}kely and Ruben C. Hartkoorn and L{\'a}szl{\'o} K{\'e}kesi and L{\'a}szl{\'o} Őrfi and Csaba Sz{\'a}ntai-Kis and Katar{\'i}na Miku{\vs}ov{\'a} and Zuzana Svetl{\'i}kov{\'a} and Jana Kordul{\'a}kov{\'a} and Valakunja Nagaraja and Adwait Anand Godbole and Natassja G. Bush and F. Collin and Anthony Maxwell and Stewart T Cole and Gy{\"o}rgy K{\'e}ri},
  journal={Tuberculosis},
  year={2015},
  volume={95 Suppl 1},
  pages={S200-6}
}
Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various institutions worldwide, including target-based approaches against several validated mycobacterial enzymes and phenotypic screens. We screened more than 17,000 compounds from Vichem's Nested Chemical Library™ using an integrated strategy involving whole cell-based assays with Corynebacterium… CONTINUE READING
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