Lead reduces tension development and the myosin ATPase activity of the rat right ventricular myocardium.

@article{Vassallo2008LeadRT,
  title={Lead reduces tension development and the myosin ATPase activity of the rat right ventricular myocardium.},
  author={Dalton Valentim Vassallo and Evandro Carlos Lebarch and Cleci Menezes Moreira and Giulia Alessandra Wiggers and Ivanita Stefanon},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2008},
  volume={41 9},
  pages={789-95}
}
Lead (Pb2+) poisoning causes hypertension, but little is known regarding its acute effects on cardiac contractility. To evaluate these effects, force was measured in right ventricular strips that were contracting isometrically in 45 male Wistar rats (250-300 g) before and after the addition of increasing concentrations of lead acetate (3, 7, 10, 30, 70, 100, and 300 microM) to the bath. Changes in rate of stimulation (0.1-1.5 Hz), relative potentiation after pauses of 15, 30, and 60 s, effect… CONTINUE READING
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