Lead optimization of antifungal peptides with 3D NMR structures analysis.

@article{Landon2004LeadOO,
  title={Lead optimization of antifungal peptides with 3D NMR structures analysis.},
  author={C{\'e}line Landon and Florent Barbault and Mich{\`e}le Legrain and Laure Menin and Marc Guenneugues and Val{\'e}rie Schott and Françoise Vovelle and Jean-Luc Dimarcq},
  journal={Protein science : a publication of the Protein Society},
  year={2004},
  volume={13 3},
  pages={703-13}
}
Antimicrobial peptides are key components of the innate immune response in most multicellular organisms. These molecules are considered as one of the most innovative class of anti-infective agents that have been discovered over the last two decades, and therefore, as a source of inspiration for novel drug design. Insect cystine-rich antimicrobial peptides with the CS alpha beta scaffold (an alpha-helix linked to a beta-sheet by two disulfide bridges) represent particularly attractive templates… CONTINUE READING

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