Lead inhibition of NMDA channels in native and recombinant receptors.

@article{Gavazzo2001LeadIO,
  title={Lead inhibition of NMDA channels in native and recombinant receptors.},
  author={Paola Gavazzo and Anna Gazzoli and Monica Mazzolini and Carla Marchetti},
  journal={Neuroreport},
  year={2001},
  volume={12 14},
  pages={3121-5}
}
NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycine affinity as well as sensitivity to ifenprodil change significantly with the days in vitro, indicating a reduction of NR2B subunit expression. Pb2+ blocked NMDA current with IC50 approximately 4 microM and this effect decreased significantly during the second week in vitro. In Xenopus laevis oocytes… CONTINUE READING