Lead inhibition of NMDA channels in native and recombinant receptors

  title={Lead inhibition of NMDA channels in native and recombinant receptors},
  author={P. Gavazzo and A. Gazzoli and M. Mazzolini and C. Marchetti},
  • P. Gavazzo, A. Gazzoli, +1 author C. Marchetti
  • Published 2001
  • Biology, Medicine
  • Neuroreport
  • NMDA channels are key targets for lead (Pb2+) neurotoxicity and Pb2+-induced inhibition of NMDA current is age- and subunit-dependent. In rat cerebellar granule cells maintained in high KCl, glycine affinity as well as sensitivity to ifenprodil change significantly with the days in vitro, indicating a reduction of NR2B subunit expression. Pb2+ blocked NMDA current with IC50 ∼4 μM and this effect decreased significantly during the second week in vitro. In Xenopus laevis oocytes expressing… CONTINUE READING
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