Lead inhibited N-methyl-D-aspartate receptor-independent long-term potentiation involved ryanodine-sensitive calcium stores in rat hippocampal area CA1.

@article{Li2006LeadIN,
  title={Lead inhibited N-methyl-D-aspartate receptor-independent long-term potentiation involved ryanodine-sensitive calcium stores in rat hippocampal area CA1.},
  author={Xin-mei Li and Y Gu and Jin-Hua She and Du Ming Zhu and Zhen Niu and Mingli Wang and Jacqueline Tien-Hsiang Chen and Limin Sun and D-Y Ruan},
  journal={Neuroscience},
  year={2006},
  volume={139 2},
  pages={463-73}
}
Lead exposure is known to be associated with cognitive dysfunction in children. Impairment of the induction of long-term potentiation (LTP) has been reported in area CA1 of rat hippocampus following lead exposure in vivo and in vitro. The present study was carried out to investigate whether the alterations of N-methyl-d-aspartate (NMDA) receptor-independent LTP following lead exposure involve internal calcium stores in hippocampus CA1 synapses. Monosynaptic field excitatory postsynaptic… CONTINUE READING