Lead-induced hypertension: role of oxidative stress.

  title={Lead-induced hypertension: role of oxidative stress.},
  author={Nosratola D. Vaziri and Domenic A. Sica},
  journal={Current hypertension reports},
  volume={6 4},
Chronic, low-level lead exposure causes hypertension in both animals and humans. The pathogenesis of lead-induced hypertension is multifactorial, including such diverse mechanisms as: inactivation of endogenous nitric oxide and downregulation of soluble guanylate cyclase by reactive oxygen species (ROS), leading to a functional deficiency in nitric oxide; heightened sympathetic activity and plasma norepinephrine together with depressed vascular and elevated renal beta-adrenergic receptor… CONTINUE READING


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