Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

@article{OBoyle2011LeadIO,
  title={Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.},
  author={Niamh M O'Boyle and Andrew J. S. Knox and Trevor T. Price and D. Clive Williams and Daniela M. Zisterer and David G. Lloyd and Mary J. Meegan},
  journal={Bioorganic & medicinal chemistry},
  year={2011},
  volume={19 20},
  pages={6055-68}
}
Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical trials and represent a new and exciting area in the treatment of cancer. Heat shock protein 90 inhibitors have huge structural diversity, and here we present the lead identification of novel inhibitors based on β-lactam and imine templates. β-Lactam 5 and imines 12 and 18 exhibit… CONTINUE READING