Lead hepatotoxicology

  title={Lead hepatotoxicology},
  author={Isabel S{\'a} and Mjp da Costa and Emanuelle Nunes da Cunha},
  journal={Toxicology and Industrial Health},
  pages={108 - 113}
The increasing use of lead (Pb) for industrial purposes has resulted in the significant increase in environmental contamination of our planet especially in concern to water and food. In this study using the electron scanning microscopy (SEM), the authors showed the effects of this metal as a result of a chronic and cumulative process. As a primary method of detection of Pb in situ, SEM was chosen, coupled with a detection system Noran Voyager of basic microanalysis X-ray (SEM-XRM), with… Expand
3 Citations
Accumulation of methylglyoxal and d-lactate in Pb-induced nephrotoxicity in rats.
It was demonstrated for the first time that urinary d-lactate might serve as the candidate marker for Pb-induced nephrotoxicity in the clinic, and metformin might be a new therapeutic candidate for P b poisoning. Expand
The Effects of Lead and Selenium on Melanoma Induction
Background: Melanoma is a malignant skin cancer and is one of the most aggressive malignancies in humans. Heavy metals, including lead, are known to cause cellular toxicity and have been studied forExpand
The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population.
This study is the first to suggest that selenium modifies the eGFR and OR in CKD induced by environmental toxicants. Expand


Ultrastructural effects of lead acetate on brain of rats
  • E. Deveci
  • Biology, Medicine
  • Toxicology and industrial health
  • 2006
Investigation of the ultrastructural effects of lead on the brain of rats found vacularisation of cell cytoplasm and degeneration in mitochondria, in the perinuclear cy toplasm, electron-dense inclusion bodies were detected, and dilation were in the endopasmic reticulum. Expand
Quantification of particles of lethal mercury in mouse viscera: high-resolution study of mercury in cells and tissues
Most intraperitoneally injected Hg was captured by liver Kupffer cells within minutes of injection, and scanning electron microscopy coupled with X-ray microanalysis is an adequate method to quantify microparticles of Hg in tissues and cells. Expand
Augmentation of mercury-induced nephrotoxicity by endotoxin in the mouse.
Overall, mice given LPS plus mercury were the most severely affected, and had significantly greater renal mercury concentration than those given mercury alone (P</=0.05). Expand
Hemolytic Effects of Sodium Selenite and Mercuric Chloride in Human Blood
Results point to a synergistic hemolytic effect of sodium selenite and mercuric chloride in human blood, suggesting new understanding on the selenium–mercury antagonism. Expand
High-resolution identification of mercury in particles in mouse kidney after acute lethal exposure – A study by Scanning Electron Microscopy coupled with X-ray Elemental Microanalysis
It is shown here that the detailed subcellular in vivo topography of microparticles of mercury in tissues can be achieved by scanning electron microscopy (SEM) coupled with X-ray elemental microanalysis (XRM), and proposed SEM-XRM as an elective approach to further investigations on the quantitative dynamics of mercury particles in the tissues. Expand
Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline.
Coexposure of rats to noninjurious doses of MCT and LPS resulted in pronounced liver injury, providing additional evidence that exposure to small amounts of LPS may be a determinant of susceptibility to food-borne hepatotoxins. Expand
[Lead poisoning and child health: integrated efforts to combat this problem].
The blood lead levels of children in the exposed group were higher than those in the control group (p < 0.05), and 314 children were found to have dosages equal or superior to 10 microg/dl, the limit stipulated by Centers for Disease Control and Prevention. Expand
Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils
The results suggest that gene expression profiles predictive of idiosyncratic liability can be generated in rats cotreated with LPS and drug and identify gene expression changes that could be explored as biomarkers for idiosyncratic toxicity and lead to enhanced understanding of the mechanism(s) underlying hepatotoxicity induced by TVX. Expand
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice
Evidence is found supporting the hypothesis that lead induces oxidative stress in hepatic cells leading to decreased oxidative stress and cellular damage initiated through free radical production by lead acetate in Swiss albino mice exposed to lead acetates. Expand
Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents.
It is concluded that inflammation should be considered as a determinant of susceptibility to intoxication by xenobiotic exposure. Expand