Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain.

@article{GarcaArenas1999LeadAE,
  title={Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain.},
  author={Guadalupe Garc{\'i}a-Arenas and Luz Claudio and Francisca P{\'e}rez-Severiano and Camilo R{\'i}os},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={1999},
  volume={50 2},
  pages={244-8}
}
The toxicity of lead (Pb) is of concern to public health due to its persistence in the environment. Brain is one of the major target organs where severe neurologic alterations may be triggered after exposure. The primary effects of lead on brain functions are thought to be a damage to the nervous system microvasculature. However, the mechanism of this toxicity is poorly understood. Nitric oxide synthase (NOS) may be a target for lead and changes in its function can result in a cascade of… CONTINUE READING