Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?

@article{Murata2009LeadTD,
  title={Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?},
  author={Katsuyuki Murata and Toyoto Iwata and Miwako Dakeishi and Kanae Karita},
  journal={Journal of Occupational Health},
  year={2009},
  volume={51}
}
Lead Toxicity: Does the Critical Level of Lead Resulting in Adverse Effects Differ between Adults and Children?: Katsuyuki Murata, et al. Department of Environmental Health Sciences, Akita University School of Medicine 
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References

SHOWING 1-10 OF 140 REFERENCES
Renal effects of environmental and occupational lead exposure.
TLDR
Blood lead levels are a poor indicator of body lead burden and reflect recent exposure, and epidemiologic studies have shown an association between blood lead levels and blood pressure, and hypertension is a cardinal feature of lead nephropathy. Expand
Critical Dose of Lead Affecting δ‐Aminolevulinic Acid Levels
TLDR
The benchmark dose method, recently used in the environmental health field in place of the no‐observed‐adverse‐effect level, was introduced into this study and it is suggested that the critical dose of BPb causing the increased levels of ALA is below 10 µg/dl. Expand
Interpreting and Managing Blood Lead Levels of Less Than 10 μg/dL in Children and Reducing Childhood Exposure to Lead: Recommendations of the Centers for Disease Control and Prevention Advisory Committee on Childhood Lead Poisoning Prevention
TLDR
Information is provided to help clinicians understand blood lead levels < 10 μg/dL, identify gaps in knowledge concerning lead levels in this range, and outline strategies to reduce childhood exposures to lead. Expand
Facilitative mechanisms of lead as a carcinogen.
TLDR
Both epidemiological and mechanistic data are consistent with a facilitative role for lead in carcinogenesis, that is, lead by itself may not be both necessary and sufficient for the induction of cancer, but at a cellular and molecular level lead may permit or enhance carcinogenic events involved in DNA damage, DNA repair, and regulation of tumor suppressor and promoter genes. Expand
Influence of occupational low-level lead exposure on renal parameters.
TLDR
The excretion of N-acetyl-beta-D-glucosaminidase appears to be the most consistent and sensitive parameter of an early effect on the tubular function. Expand
The politics of lead toxicology and the devastating consequences for children.
TLDR
This article will draw on the previous work and add new documentation of the trajectory of industry attempts to keep out of the public view the tremendous threat of lead poisoning to children. Expand
Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis
TLDR
Environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits, and an inverse relationship between blood lead concentration and IQ score is found. Expand
Environmental lead and renal effects in children.
TLDR
This study is the first to demonstrate an effect of environmental lead exposure on renal integrity in children, as demonstrated by a 14% increase of N-acetyl-beta-D-glucosaminidase per 100 micrograms/l blood lead that was indicative of renal tubular damage. Expand
Lead-induced anemia: dose-response relationships and evidence for a threshold.
TLDR
Findings suggest that blood lead levels close to the currently recommended limit value of 1.21 mumol/L (25 micrograms/dl) are associated with dose-related depression of hematocrit in young children. Expand
Lead Exposure in Children: Prevention, Detection, and Management
TLDR
There is now evidence-based guidance available for managing children with increased lead exposure and the focus in childhood lead-poisoning policy should shift from case identification and management to primary prevention, with a goal of safe housing for all children. Expand
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