Lead Exposure Is Associated with Decreased Serum Paraoxonase 1 (PON1) Activity and Genotypes

  title={Lead Exposure Is Associated with Decreased Serum Paraoxonase 1 (PON1) Activity
and Genotypes},
  author={Wan-Fen Li and Mei-Hung Pan and Meng-Chu Chung and Chi-kung Ho and H Y Chuang},
  booktitle={Environmental health perspectives},
Lead exposure causes cardiac and vascular damage in experimental animals. However, there is considerable debate regarding the causal relationship between lead exposure and cardiovascular dysfunction in humans. Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, is capable of hydrolyzing oxidized lipids and thus protects against atherosclerosis. Previous studies have shown that lead and several other metal ions are able to inhibit PON1 activity in vitro. To… CONTINUE READING
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