Lead Exposure Is Associated with Decreased Serum Paraoxonase 1 (PON1) Activity and Genotypes

@inproceedings{Li2006LeadEI,
  title={Lead Exposure Is Associated with Decreased Serum Paraoxonase 1 (PON1) Activity
and Genotypes},
  author={Wan-Fen Li and Mei-Hung Pan and Meng-Chu Chung and Chi-kung Ho and H Y Chuang},
  booktitle={Environmental health perspectives},
  year={2006}
}
Lead exposure causes cardiac and vascular damage in experimental animals. However, there is considerable debate regarding the causal relationship between lead exposure and cardiovascular dysfunction in humans. Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, is capable of hydrolyzing oxidized lipids and thus protects against atherosclerosis. Previous studies have shown that lead and several other metal ions are able to inhibit PON1 activity in vitro. To… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Inhibition of human serum arylesterase by metal chlorides

  • RM el-Gazzar, SA el-Hefny, KH Noweir, MY Shamy
  • J Inorg Biochem
  • 2003

An epidemiological reappraisal of the association between blood pressure and blood lead : a meta - analysis

  • MN Oda, JK Bielicki, TT Ho, T Berger, EM Rubin, TM Forte
  • J Hum Hypertens
  • 2002

Inhibition of paraoxonase ( PON 1 ) by heavy metals [ Abstract ]

  • J Debord, JC Bollinger, L Merle, T Dantoine
  • Toxicol Sci
  • 2002

Paraoxonase 1 Q 192 R ( PON 1 – 192 ) polymorphism is associated with reduced lipid peroxidation in Rallelecarrier but not in QQ homozygous elderly subjects on a tomatorich diet

  • A Bub, S Barth, B Watzl, K Briviba, BM Herbert, PM Luhrmann
  • Eur J Nutr
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…