Leaching of antioxidants and vulcanization accelerators from rubber closures into drug preparations.

@article{Airaudo1990LeachingOA,
  title={Leaching of antioxidants and vulcanization accelerators from rubber closures into drug preparations.},
  author={Charles B. Airaudo and Andr{\'e} Gayte-Sorbier and R. Momburg and Philippe Laurent},
  journal={Journal of biomaterials science. Polymer edition},
  year={1990},
  volume={1 4},
  pages={231-41}
}
A thin-layer chromatographic method was used to highlight the leaching into drug preparations of several constituents of elastomeric closures. Among the 150 preparations analysed, the twenty-eight local anaesthetics presented in single-dose delivery syringe-cartridges, one Epinephrine injection in prefilled syringes, eight insulin preparations and two Prednisolone acetate suspensions in the form of small volume flasks (less than or equal to 20 ml) were contaminated by one or more of the… CONTINUE READING

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