Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis

@inproceedings{Harrison2016Lcp1IA,
  title={Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis},
  author={James T. Harrison and G. Scott Lloyd and Maju Joe and Todd L Lowary and Edward H. Reynolds and Hannah Walters-Morgan and Apoorva Bhatt and Andrew M. Lovering and Gurdyal S Besra and Luke J. Alderwick},
  booktitle={mBio},
  year={2016}
}
UNLABELLED Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has a unique cell envelope which accounts for its unusual low permeability and contributes to resistance against common antibiotics. The main structural elements of the cell wall consist of a cross-linked network of peptidoglycan (PG) in which some of the muramic acid residues are covalently attached to a complex polysaccharide, arabinogalactan (AG), via a unique α-l-rhamnopyranose-(1→3)-α-d-GlcNAc-(1→P) linker… CONTINUE READING
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