Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.

@article{Lovatt2006LckRT,
  title={Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.},
  author={Matthew J Lovatt and Andrew Filby and Valentino Parravicini and Guy Werlen and Ed Palmer and Rose Zamoyska},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 22},
  pages={8655-65}
}
The src family kinases p56lck (Lck) and p59fyn (Fyn) are the most proximal signaling molecules to be activated downstream of the T-cell receptor. Using an inducible transgenic model, we can regulate the expression of Lck in primary T cells and ask how the signaling cascade and differentiation potential are affected by the absence or the presence of reduced levels of Lck. We show that in naïve T cells, Lck controls the threshold of activation by preferentially regulating multiple signaling… CONTINUE READING