Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions.

Abstract

Maturational changes at the CD4(-)CD8(-) double negative (DN) to CD4(+)CD8(+) double positive (DP) transition are dependent on signals generated via the pre-T cell receptor (TCR) and the nonreceptor protein tyrosine kinase p56(lck) (Lck). How Lck activities are stimulated or relayed after pre-TCR formation remains obscure. Our structure-function mapping of… (More)

Topics

6 Figures and Tables

Cite this paper

@article{Lin2000LckDD, title={Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions.}, author={K. Lin and Nicola Longo and Xun Wang and Jill A. Hewitt and K. M. Abraham}, journal={The Journal of experimental medicine}, year={2000}, volume={191 4}, pages={703-16} }