Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts.

@article{Filipp2008LckdependentFA,
  title={Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts.},
  author={Dominik Filipp and Behrouz Moemeni and Alessandra Ferzoco and Kirishanthy Kathirkamathamby and Jenny Xinyan Zhang and Ondřej Ballek and Dominique Davidson and Andr{\'e} Veillette and Michael Julius},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 39},
  pages={26409-22}
}
Mechanisms regulating the activation and delivery of function of Lck and Fyn are central to the generation of the most proximal signaling events emanating from the T cell antigen receptor (TcR) complex. Recent results demonstrate that lipid rafts (LR) segregate Lck and Fyn and play a fundamental role in the temporal and spatial coordination of their activation. Specifically, TcR-CD4 co-aggregation-induced Lck activation outside LR results in Lck translocation to LR where the activation of LR… CONTINUE READING