Lck and the nature of the T cell receptor trigger.

  title={Lck and the nature of the T cell receptor trigger.},
  author={Simon J Davis and Philip Anton van der Merwe},
  journal={Trends in immunology},
  volume={32 1},
Exactly how ligand binding 'triggers' T cell receptor (TCR) phosphorylation is unclear. It has been proposed that ligand engagement by the TCR somehow activates the Src kinase Lck, which in turn phosphorylates the receptor. Recent data, however, suggest instead that a significant fraction of the Lck in resting T cells is already activated and that the proportion of active Lck does not change during the early stages of T cell activation. We argue that, caveats notwithstanding, these new… CONTINUE READING

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