Lbos 02-03 the Infiltrating Macrophage-secreted Galectin-3 Plays an Essential Role in Cardiac Fibrosis and Diastolic Function in Murine Pressure-overload Model.

Abstract

OBJECTIVE Cardiac fibrosis is the major pathophysiological process, contributing to the development of diastolic heart failure. We examine the role of macrophage-derived galectin-3 (gal-3) in cardiac fibrosis and diastolic function in response to transverse aortic constriction (TAC). DESIGN AND METHOD wild-type (WT) and gal-3 knock-out (KO) mice subjected… (More)
DOI: 10.1097/01.hjh.0000501503.60171.8b

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