Lazaroids enhance skeletal myogenesis in primary cultures of dystrophin-deficient mdx mice.

@article{Metzinger1994LazaroidsES,
  title={Lazaroids enhance skeletal myogenesis in primary cultures of dystrophin-deficient mdx mice.},
  author={Laurent Metzinger and A. C. Passaquin and Aline Vernier and Nathalie Thiriet and Jean Marie Warter and Philippe Poindron},
  journal={Journal of the neurological sciences},
  year={1994},
  volume={126 2},
  pages={138-45}
}
Growing evidence suggests a role for free radicals in the degeneration of dystrophin-deficient muscle (as observed in Duchenne muscular dystrophy). We therefore decided to test the action of the lazaroid antioxidant compounds on primary skeletal muscle cell cultures derived from an animal model of Duchenne muscular dystrophy, the mdx mouse. Both vitamin E-derived U-83836E and glucocorticoid-derived U-74389F enhanced myogenesis of dystrophin-deficient cultures as determined by the number of… CONTINUE READING