Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

@article{Pommier2016LayingAT,
  title={Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action},
  author={Yves Pommier and Mark J. O’Connor and Johann de Bono},
  journal={Science Translational Medicine},
  year={2016},
  volume={8},
  pages={362ps17-362ps17}
}
Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism of action by PARP “trapping” and what this means for both clinical monotherapy and combination with chemotherapeutic agents. 
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