Layer variations of long-term depression in rat visual cortex.

@article{Rao2004LayerVO,
  title={Layer variations of long-term depression in rat visual cortex.},
  author={Yan Rao and Nigel Daw},
  journal={Journal of neurophysiology},
  year={2004},
  volume={92 5},
  pages={
          2652-8
        }
}
In vitro long-term depression (LTD) is thought to be a model for the loss of cortical responsiveness to an eye deprived of vision during the critical period. Using whole cell recording, the present study investigates the mechanisms of LTD in vitro across layers in developing rat visual cortex. LTD was induced in layers II/III, V, and VI but not layer IV with 10-min 1-Hz stimulation paired with postsynaptic depolarization. LTD in layers II/III and V could be blocked by the N-methyl-D-aspartate… CONTINUE READING

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