Layer-specific modulation of neocortical dendritic inhibition during active wakefulness

@article{Muoz2017LayerspecificMO,
  title={Layer-specific modulation of neocortical dendritic inhibition during active wakefulness},
  author={William Mu{\~n}oz and Robin Tremblay and Daniel Levenstein and Bernardo Rudy},
  journal={Science},
  year={2017},
  volume={355},
  pages={954-959}
}
γ-Aminobutyric acid (GABA)ergic inputs are strategically positioned to gate synaptic integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal dynamics during behavior are poorly understood. Using an optical-tagging electrophysiological approach to record and label somatostatin-expressing (Sst) interneurons (GABAergic neurons specialized for dendritic inhibition), we discovered a layer-specific modulation of their activity in behaving mice. Sst interneuron subtypes… CONTINUE READING
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