Layer-specific cholinergic control of human and mouse cortical synaptic plasticity

  title={Layer-specific cholinergic control of human and mouse cortical synaptic plasticity},
  author={Matthijs B. Verhoog and Joshua Obermayer and Christian A. Kortleven and Ren{\'e} Wilbers and Jordi Wester and Johannes C. Baayen and Christiaan P. J. de Kock and Rhiannon M. Meredith and Huibert D. Mansvelder},
  booktitle={Nature communications},
Individual cortical layers have distinct roles in information processing. All layers receive cholinergic inputs from the basal forebrain (BF), which is crucial for cognition. Acetylcholinergic receptors are differentially distributed across cortical layers, and recent evidence suggests that different populations of BF cholinergic neurons may target specific prefrontal cortical (PFC) layers, raising the question of whether cholinergic control of the PFC is layer dependent. Here we address this… CONTINUE READING
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The authors declare no competing financial interests

  • R. M. Holmgren C.D. Weidum M. Burnashev N. Meredith, H. D. Increased threshold for spike-timing-dependent Mansvelder, +13 authors H.D.M. Additional information Competing financial interes acquisition
  • Reprints and permission information is available…
  • 2016

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