Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment.

@article{Deng2013LayerbylayerNF,
  title={Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment.},
  author={Z. John Deng and Stephen W. Morton and Elana Ben-Akiva and Erik C. Dreaden and Kevin E. Shopsowitz and Paula T Hammond},
  journal={ACS nano},
  year={2013},
  volume={7 11},
  pages={9571-84}
}
A single nanoparticle platform has been developed through the modular and controlled layer-by-layer process to codeliver siRNA that knocks down a drug-resistance pathway in tumor cells and a chemotherapy drug to challenge a highly aggressive form of triple-negative breast cancer. Layer-by-layer films were formed on nanoparticles by alternately depositing siRNA and poly-l-arginine; a single bilayer on the nanoparticle surface could effectively load up to 3500 siRNA molecules, and the resulting… CONTINUE READING
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