Layer-by-layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts.

@article{Crouzier2009LayerbylayerFA,
  title={Layer-by-layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts.},
  author={Thomas Crouzier and Kefeng Ren and Claire Nicolas and Christian Roy and Catherine Picart},
  journal={Small},
  year={2009},
  volume={5 5},
  pages={598-608}
}
Efficient delivery of growth or survival factors to cells is one of the most important long-term challenges of current cell-based tissue engineering strategies. The extracellular matrix acts as a reservoir for a number of growth factors through interactions with its components. In the matrix, growth factors are protected against circulating proteases and locally concentrated. Thus, the localized and long-lasting delivery of a matrix-bound recombinant human bone morphogenetic protein 2 (rhBMP-2… CONTINUE READING
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