Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network.

  title={Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network.},
  author={Sundar P. Authimoolam and Andrew L Lakes and David A. Puleo and Thomas D Dziubla},
  journal={Macromolecular bioscience},
  volume={16 2},
Mucin networks are lubricous biofunctional coats formed through the continuous deposition of mucin glycoproteins. Previously, we demonstrated the synthesis of a mucin mimic using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer approach. These networks recreate the fibrous nature of mucin and can serve as a drug-releasing network. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition… CONTINUE READING
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