Laxative poisoning: toxicological analysis of bisacodyl and its metabolite in urine, serum, and stool.

  title={Laxative poisoning: toxicological analysis of bisacodyl and its metabolite in urine, serum, and stool.},
  author={Keiko Kudo and Carolina K Miyazaki and Ryo Kadoya and T. Imamura and Narumi Jitsufuchi and Noriaki Ikeda},
  journal={Journal of analytical toxicology},
  volume={22 4},
An 11-year-old boy was hospitalized because of severe diarrhea (over 5 L/day). The child survived; however, the diarrhea continued while he was given intravenous fluids and his electrolyte balance was closely supervised. Based on observation of the patient and his family in the hospital, surreptitious administration of a poison by his mother was suspected, and toxicological analysis was carried out on stools from the boy and on medicine administered to him by his mother. Bisacodyl, a cathartic… Expand
Screening for surreptitious laxative abuse
  • A. Duncan
  • Medicine
  • Annals of clinical biochemistry
  • 2000
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Spectrophotometric Determination of Bisacodyl and Piribedil
ABSTRACT Simple spectrophotometric methods are described for the assay of bisacodyl (BIS) and piribedil (PIR) based on charge‐transfer and ion‐pair complexation reactions. The first method is basedExpand
LC-MS/MS method for the detection of common laxatives.
This work describes an LC-MS/MS procedure for the detection of four metabolites related to common laxatives-desacetylbisacodyl, aloe-emodin, emod in, and rhein, which consists of deconjugation of analytes in urine followed by organic solvent extraction. Expand
Size-exclusion flow extraction of bisphenol A in human urine for liquid chromatography-mass spectrometry.
The present approach includes the addition of 13C(12)-BPA, enzymatic deconjugation, and the proposed sample preparation method, which enables the determination of standards and may be applied to the detection of trace amounts of BPA in human urine samples. Expand
This systematic review contains a huge collection of references for chemicals, natural products, plants having laxative action and also provides the foods like prunes, pears, bran cereals, chemicals like salts of magnesium, cellulose, plants like senna, encourage intestinal contractions and easier time moving of bowels. Expand
Psychological Co-morbidities of Irritable Bowel Syndrome
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Stability indicating analysis of bisacodyl by partial least squares regression, spectral residual augmented classical least squares and support vector regression chemometric models: A comparative study
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Light-induced metal-free transformations of unactivated pyridotriazoles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02448d
A novel light-induced metal-free method for conversion of unactivated pyridotriazoles into pyridyl carbenes was developed, which allowed for incorporation of arylmethylpyridyl moiety into diverseExpand
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Quantitation of a bisacodyl metabolite in urine for the diagnosis of laxative abuse.
The final diagnosis of laxative abuse was arrived at after identification and quantitation of a bisacodyl metabolite in the urine from the patient, and the metabolite was bisacODYl disphenol. Expand
Chronic diarrhea due to surreptitious use of bisacodyl: case reports and methods for detection.
It is recommended that urinalysis and, in some cases, stool analysis for bisacodyl should be considered in the diagnostic assessment for surreptitious use of laxatives. Expand
[Pharmacokinetics and laxative effect of bisacodyl following administration of various dosage forms].
The absorption and the plasma level profile is studied and the laxative effect after the administration of various dosage forms are correlated and plasma levels were below the detection limit. Expand
Qualitative and quantitative analysis of some synthetic, chemically acting laxatives in urine by gas chromatography-mass spectrometry.
The GC-MS method proved to be suitable for measuring urine concentrations for at least four days after administration of a single oral low therapeutic dose of the laxatives to sixteen healthy volunteers. Expand
Diagnosis of magnesium-induced diarrhea.
Quantitative fecal analysis for soluble magnesium is an accurate method of diagnosing magnesium-induced diarrhea and was indicated that excessive ingestion of magnesium was an important cause of chronic diarrhea in 15 patients with chronic diarrhea. Expand
Polle syndrome: chronic diarrhea in Munchausen's child.
A child with a complex history of chronic diarrhea and a seizure disorder, with multiple nondiagnostic previous evaluations, is presented and the source of this child's chronic disorder was confirmed to be exogenous drug administration by the mother. Expand
Munchausen syndrome by proxy: an unexpected cause of severe chronic diarrhoea in a child
Munchausen syndrome by proxy by proxy is an unexpected cause of severe chronic diarrhoea in a child. Expand
Laxative abuse and secretory diarrhoea.
Three children with chronic diarrhoea secondary to laxative abuse are reported. Growth disturbance, a previously unrecognised feature of this form of abuse, is recorded.
A 3-year-old boy's chronic diarrhea and unexplained death.
The fatal case of a three year-old boy hospitalized for chronic diarrhea is described. The diagnosis of Munchausen's by Proxy is discussed, and the approach to such cases is explored.
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  • 1991