• Corpus ID: 92979974

Laxative, Antiinflammatory and Analgesic Effects of Cassia Siamea Lam (Fabaceae) Leaves Aqueous Extract

@inproceedings{Ntandou2018LaxativeAA,
  title={Laxative, Antiinflammatory and Analgesic Effects of Cassia Siamea Lam (Fabaceae) Leaves Aqueous Extract},
  author={Nsonde Ntandou and Etou Ossibi and Elion Itou},
  year={2018}
}

• Nsonde Ntandou, Etou Ossibi, E. Itou
• Published 2018
• Medicine

Purpose: The objective of this study is to evaluate laxative, anti-inflammatory and analgesic activities of the aqueous extract of C. siamea leaves to contribute to the development of an improved traditional phytomedicine based on this plant. Material and Methods: At doses of 400 and 800 mg / kg administered orally, the aqueous extract of Cassia siamea (Fabaceae) leaves was evaluated in rats. Results: in normal and constipated rats the aqueous extract of the leaves of Cassia siamea significantly decreases, the latency of the first fecal excretion (*** p <0.001) and significantly increased the fecal excretion rate (** * p <0.001), and the total amount of excreted feces (*** p <0.001 and * p <0.05). This extract, also, showed interesting activity against acute inflammation of the paw edema induced by carrageenan, very significant after 1:00 (*** p <0.001), and against chronic inflammation of the granuloma cotton pellet (***p <0.05). The analgesic activity against cramps induced by acetic acid was less significant (* p <0.05). Alkaloids, polyphenols, terpenoids, steroids, anthraquinones, cardiotonic glycosides and anthocyanins have been identified in this plant. Conclusion: Already used as food, the leaves of Cassia siamea are likely to serve, can be use in the development of an efficient and better tolerated laxative and anti-inflammatory medicine.