• Corpus ID: 73620234

Lawrence Berkeley National Laboratory Recent Work Title Multiple signaling systems target a core set of transition metal homeostasis genes using similar binding motifs Permalink

  title={Lawrence Berkeley National Laboratory Recent Work Title Multiple signaling systems target a core set of transition metal homeostasis genes using similar binding motifs Permalink},
  author={Megan E. Garber and Lara Rajeev and Alexey E Kazakov and Jessica Trinh and Duy Masuno and Mitchell G. Thompson and Nurgul Kaplan and Joyce Luk and Pavel S. Novichkov and Aindrila Mukhopadhyay},


Copper tolerance and virulence in bacteria.
Current understanding of copper tolerance in bacteria is summarized, and the extent to which these pathways contribute to bacterial virulence within the host is summarized.
An intimate link: two-component signal transduction systems and metal transport systems in bacteria.
Evidence is presented of how bacterial TCSTSs modulate metal ion homeostasis and also how metal ions function to control the activities of these signaling systems linked with bacterial survival and virulence.
Enzymatic assembly of DNA molecules up to several hundred kilobases
We describe an isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5′ exonuclease, a DNA polymerase and a DNA ligase. First we recessed
Signal integration in bacterial two-component regulatory systems.
An emerging class of proteins-termed TCS connectors-modulate the output of TCSs by affecting the phosphorylation state of response regulators.
A Copper-Activated Two-Component System Interacts with Zinc and Imipenem Resistance in Pseudomonas aeruginosa
CopR is a new negative regulator of OprD porin and that it links Zn, Cu, and imipenem resistances by interacting with the CzcRS TCS.
Differential analysis of RNA-seq incorporating quantification uncertainty
A method for the differential analysis of gene expression data that utilizes bootstrapping in conjunction with response error linear modeling to decouple biological variance from inferential variance is described.
Near-optimal probabilistic RNA-seq quantification
Kallisto pseudoaligns reads to a reference, producing a list of transcripts that are compatible with each read while avoiding alignment of individual bases, which removes a major computational bottleneck in RNA-seq analysis.
Unipro UGENE: a unified bioinformatics toolkit
Unipro UGENE integrates widely used bioinformatics tools within a common user interface and provides visualization modules for biological objects such as annotated genome sequences, Next Generation Sequencing (NGS) assembly data, multiple sequence alignments, phylogenetic trees and 3D structures.
The Cus efflux system removes toxic ions via a methionine shuttle
  • C. Su, F. Long, E. Yu
  • Biology
    Protein science : a publication of the Protein Society
  • 2011
Genetic and structural analyses suggest that the CusA pump is capable of picking up the metal ions from both the periplasm and cytoplasm, and proposed a stepwise shuttle mechanism for this pump to extrudeMetal ions from the cell.
Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport
The crystal structure indicates that CusA has, in addition to the three-methionine metal-binding site, four methionine pairs—three located in the transmembrane region and one in the periplasmic domain, which directly suggests a plausible pathway for ion export.