Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.

@article{Patel2004LatticeSA,
  title={Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.},
  author={Sangita B Patel and Patricia M. Cameron and Betsy Frantz-Wattley and Edward A O'neill and Joseph W. Becker and Giovanna Scapin},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1696 1},
  pages={67-73}
}
Mitogen-activated protein (MAP) kinase p38 alpha is activated in response to environmental stress and cytokines, and plays a significant role in inflammatory responses. For these reasons, it is an important target for the treatment of a wide range of inflammatory and autoimmune diseases. The crystals of p38 alpha that we obtained by published procedures were usually small, quite mosaic, and difficult to reproduce and thus posed a difficulty for the intensive high-resolution studies required for… CONTINUE READING
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