Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries.

@article{Sun2015Lats1DC,
  title={Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries.},
  author={Tianyanxin Sun and Melissa E. Pepling and Francisco Javier Hern{\'a}ndez D{\'i}az},
  journal={Biology of reproduction},
  year={2015},
  volume={93 1},
  pages={22}
}
The Hippo signaling pathway is essential for regulating proliferation and apoptosis in mammalian cells. The LATS1 kinase is a core member of the Hippo signaling pathway that phosphorylates and inactivates the transcriptional co-activators YAP1 and WWTR1. Deletion of Lats1 results in low neonate survival and ovarian stromal tumors in surviving adults, but the effects of Lats1 on early follicular development are not understood. Here, the expression of Hippo pathway components including Wwtr1… CONTINUE READING