Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.

@article{McNeill2017Lats12RY,
  title={Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.},
  author={Helen McNeill and Antoine Reginensi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2017},
  volume={28 3},
  pages={
          852-861
        }
}
In the kidney, formation of the functional filtration units, the nephrons, is essential for postnatal life. During development, mesenchymal progenitors tightly regulate the balance between self-renewal and differentiation to give rise to all nephron epithelia. Here, we investigated the functions of the Hippo pathway serine/threonine-protein kinases Lats1 and Lats2, which phosphorylate and inhibit the transcriptional coactivators Yap and Taz, in nephron progenitor cells. Genetic deletion of… CONTINUE READING
3
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

The Hippo pathway in normal development and cancer

VIEW 1 EXCERPT
CITES BACKGROUND

Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis.

VIEW 1 EXCERPT
CITES BACKGROUND